Vasculitis inducida por medicamentos

Estudio de 13 casos

Abstract

Thirteen patients with well documented druginduced vasculitis seen over a seven year period are reported. Nine were females; the mean age of all patients was 47.7 years (range 25 to 84). The main clinical manifestations were papulo-erythcmatous lesions (six cases), palpable purpura (four cases), chronic urticaria and necrotic skin ulcers (three cases), and generalized pruritus (six cases). Some patients had more than one manifestation. Seven cases were lymphomonocytic, one case leucocytoclastic and five cases mixed. Two patients developed fibrous myopathy secondary to the chronic use of D-propoxyphene. The pathogenesis of drug-induced vasculitis is not completely understood. It is believed that immunologic phenomena, of humoral and cellular type, are involved. Fibrous myopathy was most likely secondary to an inflammatory process due to mechanical irritation by needles or to drugs. This is the largest series of drug-induced vasculitis in the literature and the first report of fibrous myopathy caused by D-propoxyphene