El signo de Leser-Trélat: ¿Un predictor de neoplasias útil en clínica?

Abstract

Purpose: the sign of Leser-Trélat conjugates the simultaneous presence of eruptive seborrheic keratoses with a malignancy, but there are reports of patients with keratosis with or without neoplasia. The establishment of whether there is evidence for this association to consider the potential for the occurrence of such skin lesions as an early finding of malignant neoplasms was sought.

Data Sources: a systematic review of the literature located on Medline, Cochrane, Lilacs, Schoolar Google and Imbiomed.

Study Selection: all articles related to eruptive seborrheic keratosis and cancer, with no limit on age, sex, type of article or language were evaluated.

Data Extraction: 668 abstracts were read and 120 full articles were reviewed, 66 used in this report.

Results: the evidence supporting the association between sudden seborrheic keratosis and cancer is poor: there are only four case-control studies whose results do not support this association.

Conclusions: the vast majority of publications are the product of chance finding of the two entities and not the result of a systematic search of one of them when the other appears, reflecting a kind of selection bias in publishing such cases