Uncommon adverse reactions to antibiotics: agranulocytosis by vancomycin

Abstract

The drug-induced blood dyscrasias are caused by the interaction between it and hematopoietic cells"(TM)s specific receptors. Potential mechanisms like bone marrow toxicity and peripheral cell abnormality have been identified as responsible for hematological disturbances. Other known factors involved are hypersensitivity, immune defects, infections or unknown mechanisms. The first report of drug induced agranulocytosis was described on 1930"(TM)s. The drugs with most relative risk of agranulocytosis or aplastic anemia are the antithyroid, carbamazepine, sulfonamides, sulfonylureas, indomethacin, piroxicam and extended. In this article we report and discuss the clinical presentation of idiosyncratic agranulocytosis in a patient treated with vancomycin, posterior recovery with suspension of this antimicrobial