Obesity anmetabolicd syndrome

Abstract

Metabolic syndrome comprises a series of alterations associated with insulin resistance. The adipose tissue, as an active endocrine organ, produces several mediators that act both directly and indirectly on insulin sensitivity in several tissues. This paper is designed to review the physiological mechanisms of insulin activity and the way in which they may be affected by the action of several hormones originating in the adipose tissue, including leptin, tumor necrosis factor alpha and adiponectin.