Behavior of high sensitivity Troponin I levels in patients with chronic kidney disease stage 5 on hemodialysis

Abstract

"Clinical Research Work - Internists" award at the X SOLAMI Conference and XXVI ACMI-ACP Congress in Cartagena, Colombia, 17th-20th August 2017

Introduction: patients with chronic kidney disease (CKD) have a higher prevalence of troponin elevation, even in the absence of acute coronary syndrome. The objective of this study was to evaluate the behavior of ultrasensitive troponin I in patients with CKD before and after a hemodialysis session.

Design: pseudoexperiment.

Methodology: patients older than 18 years with stage 5 CKD in hemodialysis were included. Patients with active heart condition, cardiac device use, percutaneous coronary intervention or history of cardiac surgery were excluded from the study. Troponin values above the 99th percentile were considered positive before hemodialysis and an elevation of more than 20% was considered positive according to the universal definition of myocardial infarction. All patients signed an informed consent.

Results: 33 patients with an average age of 56 years were included. One patient presented high troponin before (3%) and two patients had it elevated after dialysis (6%). There were no statistical differences between the two groups (p-value 0.8506). The same patient with increased troponin before, elevated it after dialysis, which means that only one patient raised troponin during the hemodialysis session